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pentobarbital will enhance the amount or impact of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers decreased ivosidenib plasma concentrations.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â